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1

Formation of Pyroglutamic Acid from N-Terminal Glutamic Acid in Immunoglobulin Gamma Antibodies

Chelius, Dirk, Jing, Kay, Lueras, Alexis, Rehder, Douglas S., Dillon, Thomas M., Vizel, Alona, Rajan, Rahul S., Li, Tiansheng, Treuheit, Michael J., Bondarenko, Pavel V.

Journal:

Analytical Chemistry

Year:

2006

Language:

english

File:

PDF, 159 KB

english, 2006

2

The LC/MS analysis of glycation of IgG molecules in sucrose containing formulations

Himanshu S. Gadgil, Pavel V. Bondarenko, Gary Pipes, Doug Rehder, Arnold McAuley, Natalie Perico, Tom Dillon, Margaret Ricci, Michael Treuheit

Journal:

Journal of Pharmaceutical Sciences

Year:

2007

Language:

english

File:

PDF, 487 KB

english, 2007

3

LC/MS analysis of complex multiglycosylated human α1-acid glycoprotein as a model for developing identification and quantitation methods for intact glycopeptide analysis

Melanie M. Ivancic, Himanshu S. Gadgil, H. Brian Halsall, Michael J. Treuheit

Journal:

Analytical Biochemistry

Year:

2010

Language:

english

File:

PDF, 599 KB

english, 2010

4

Formulation of Neulasta® (pegfilgrastim)

Deirdre Murphy Piedmonte, Michael J. Treuheit

Journal:

Advanced Drug Delivery Reviews

Year:

2008

Language:

english

File:

PDF, 280 KB

english, 2008

5

O-Fucosylation of an antibody light chain: Characterization of a modification occurring on an IgG1 molecule

Valliere-Douglass, J. F, Brady, L. J, Farnsworth, C., Pace, D., Balland, A., Wallace, A., Wang, W., Treuheit, M. J, Yan, B.

Journal:

Year:

2008

Language:

english

File:

PDF, 668 KB

english, 2008

6

Kultursoziologische Erforschungder Welt- Und Lebensanschauung

Treuheit, Klaus

Journal:

European Journal of Sociology

Year:

1985

Language:

german

File:

PDF, 748 KB

german, 1985

7

Neurologische Erkankungen – Pathophysiologie, Diagnostik und Therapie neuromuskulärer Erkrankungen

Year:

2010

Language:

german

File:

PDF, 825 KB

german, 2010

8

High-Throughput Screening and Analysis of Charge Variants of Monoclonal Antibodies in Multiple Formulations

Alekseychyk, Larysa, Su, Cheng, Becker, Gerald W., Treuheit, Michael J., Razinkov, Vladimir I.

Journal:

Year:

2017

Language:

english

File:

PDF, 973 KB

english, 2017

9

Isolation of clobazam–orosomucoid complexes from Patients' sera

Michael Treuheit, H. Brian Halsall

Journal:

Biomedical Chromatography

Year:

1992

Language:

english

File:

PDF, 1.46 MB

english, 1992

10

Middle-down fragmentation for the identification and quantitation of site-specific methionine oxidation in an IgG1 molecule

Gary D. Pipes, Phillip Campbell, Pavel V. Bondarenko, Bruce A. Kerwin, Michael J. Treuheit, Himanshu S. Gadgil

Journal:

Journal of Pharmaceutical Sciences

Year:

2010

Language:

english

File:

PDF, 391 KB

english, 2010

11

Characterization of site-specific glycation during process development of a human therapeutic monoclonal antibody

Amanda K. Miller, David M. Hambly, Bruce A. Kerwin, Michael J. Treuheit, Himanshu S. Gadgil

Journal:

Journal of Pharmaceutical Sciences

Year:

2011

Language:

english

File:

PDF, 288 KB

english, 2011

12

Reversibility of Cysteine Labeling by 4-(Aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole

M.J. Treuheit, T.L. Kirley

Journal:

Analytical Biochemistry

Year:

1993

File:

PDF, 495 KB

1993

13

Identification of cysteinylation of a free cysteine in the Fab region of a recombinant monoclonal IgG1 antibody using Lys-C limited proteolysis coupled with LC/MS analysis

Himanshu S. Gadgil, Pavel V. Bondarenko, Gary D. Pipes, Thomas M. Dillon, Douglas Banks, Jeffrey Abel, Gerd R. Kleemann, Michael J. Treuheit

Journal:

Analytical Biochemistry

Year:

2006

Language:

english

File:

PDF, 975 KB

english, 2006

14

Top-down N-terminal sequencing of Immunoglobulin subunits with electrospray ionization time of flight mass spectrometry

Da Ren, Gary D. Pipes, David Hambly, Pavel V. Bondarenko, Michael J. Treuheit, Himanshu S. Gadgil

Journal:

Analytical Biochemistry

Year:

2009

Language:

english

File:

PDF, 6.07 MB

english, 2009

15

An improved trypsin digestion method minimizes digestion-induced modifications on proteins

Da Ren, Gary D. Pipes, Dingjiang Liu, Liang-Yu Shih, Andrew C. Nichols, Michael J. Treuheit, David N. Brems, Pavel V. Bondarenko

Journal:

Analytical Biochemistry

Year:

2009

Language:

english

File:

PDF, 555 KB

english, 2009

16

Reversed-phase liquid chromatography of immunoglobulin G molecules and their fragments with the diphenyl column

Da Ren, Gary D. Pipes, David M. Hambly, Pavel V. Bondarenko, Michael J. Treuheit, David N. Brems, Himanshu S. Gadgil

Journal:

Journal of Chromatography A

Year:

2007

Language:

english

File:

PDF, 559 KB

english, 2007

17

Reversed-phase liquid chromatography–mass spectrometry of site-specific chemical modifications in intact immunoglobulin molecules and their fragments

Da Ren, Gary Pipes, Gang Xiao, Gerd R. Kleemann, Pavel V. Bondarenko, Michael J. Treuheit, Himanshu S. Gadgil

Journal:

Journal of Chromatography A

Year:

2008

Language:

english

File:

PDF, 213 KB

english, 2008

18

Improving Mass Accuracy of High Performance Liquid Chromatography/Electrospray Ionization Time-of-Flight Mass Spectrometry of Intact Antibodies

Himanshu S. Gadgil, Gary D. Pipes, Thomas M. Dillon, Michael J. Treuheit, Pavel V. Bondarenko

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2006

Language:

english

File:

PDF, 268 KB

english, 2006

19

Comparison of LC and LC/MS methods for quantifyingN-glycosylation in recombinant IgGs

Sandipan Sinha, Gary Pipes, Elizabeth M. Topp, Pavel V. Bondarenko, Michael J. Treuheit, Himanshu S. Gadgil

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2008

Language:

english

File:

PDF, 702 KB

english, 2008

20

Automated tryptic digestion procedure for HPLC/MS/MS peptide mapping of immunoglobulin gamma antibodies in pharmaceutics

Dirk Chelius, Gang Xiao, Andrew C. Nichols, Alona Vizel, Bing He, Thomas M. Dillon, Douglas S. Rehder, Gary D. Pipes, Edmund Kraft, Asha Oroska, Michael J. Treuheit, Pavel V. Bondarenko

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2008

Language:

english

File:

PDF, 1.24 MB

english, 2008

21

Ethanol-sodium chloride-phosphate mobile phase for size-exclusion chromatography of poly(ethylene glycol) modified proteins

Joseph J. Ratto, Sheila R. O'Conner, Adrian R. Distler, Gay-May Wu, David Hummel, Michael J. Treuheit, Alan C. Herman, Janice M. Davis

Journal:

Journal of Chromatography A

Year:

1997

Language:

english

File:

PDF, 448 KB

english, 1997

22

Removal of the fluorescent 4-(aminosulfonyl)-2,1,3-benzoxadiazole label from cysteine-containing peptides

Scott L Lauren, Michael J Treuheit

Journal:

Journal of Chromatography A

Year:

1998

Language:

english

File:

PDF, 136 KB

english, 1998

23

Photochemical degradation of citrate buffers leads to covalent acetonation of recombinant protein therapeutics

John F. Valliere-Douglass, Lisa Connell-Crowley, Randy Jensen, Paul D. Schnier, Egor Trilisky, Matt Leith, Brian D. Follstad, Jennifer Kerr, Nathan Lewis, Suresh Vunnum, Michael J. Treuheit, Alain Bal

Journal:

Protein Science

Year:

2010

Language:

english

File:

PDF, 718 KB

english, 2010

24

Optimization and Applications of CDAP Labeling for the Assignment of Cysteines

Gary D. Pipes, Andrew A. Kosky, Jeffrey Abel, Yu Zhang, Michael J. Treuheit, Gerd R. Kleemann

Journal:

Pharmaceutical Research

Year:

2005

Language:

english

File:

PDF, 559 KB

english, 2005

25

Sodium Chloride Enhances the Storage and Conformational Stability of BDNF and PEG-BDNF

William J. Callahan, Linda O. Narhi, Andrew A. Kosky, Michael J. Treuheit

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 227 KB

english, 2001

26

Sex Differences in Length of Survival with Malignant Astrocytoma, But not with Glioblastoma

Sabine Diete, Tim Treuheit, Knut Dietzmann, Uwe Schmidt, Clans-W. Wallesch

Journal:

Journal of Neuro-Oncology

Year:

2001

Language:

english

File:

PDF, 54 KB

english, 2001

27

PEGylation Prevents the N-Terminal Degradation of Megakaryocyte Growth and Development Factor

Patricia I. Guerra, Christine Acklin, Andrew A. Kosky, Janice M. Davis, Michael J. Treuheit, David N. Brems

Journal:

Pharmaceutical Research

Year:

1998

File:

PDF, 513 KB

1998

28

Inverse Relationship of Protein Concentration and Aggregation

Michael J. Treuheit, Andrew A. Kosky, David N. Brems

Journal:

Pharmaceutical Research

Year:

2002

Language:

english

File:

PDF, 191 KB

english, 2002

29

Characterization and Stability ofN-terminally PEGylated rhG-CSF

Olaf B. Kinstler, David N. Brems, Scott L. Lauren, Amiee G. Paige, James B. Hamburger, Michael J. Treuheit

Journal:

Pharmaceutical Research

Year:

1996

File:

PDF, 1.23 MB

1996

30

Aggregation of granulocyte-colony stimulating factor in vitro involves a conformationally altered monomeric state

Stephen W. Raso, Jeff Abel, Jesse M. Barnes, Kevin M. Maloney, Gary Pipes, Michael J. Treuheit, Jonathan King, David N. Brems

Journal:

Protein Science

Year:

2005

Language:

english

File:

PDF, 312 KB

english, 2005

31

Modulation of protein aggregation by polyethylene glycol conjugation: GCSF as a case study

Rahul S. Rajan, Tiansheng Li, Mohini Aras, Christopher Sloey, Weston Sutherland, Hiromi Arai, Robert Briddell, Olaf Kinstler, Alexis M.K. Lueras, Yu Zhang, Heather Yeghnazar, Michael Treuheit, David N

Journal:

Protein Science

Year:

2006

Language:

english

File:

PDF, 646 KB

english, 2006

32

Thermodynamic Compensation upon Binding to Exosite 1 and the Active Site of Thrombin

Treuheit, Nicholas A., Beach, Muneera A., Komives, Elizabeth A.

Journal:

Year:

2011

Language:

english

File:

PDF, 1.99 MB

english, 2011

33

Purification of the glycosylated beta subunit of (Na,K)-ATPase by lectin affinity chromatography

M. J. Treuheit, A. Ataei, T. L. Kirley, E. T. Wallick

Journal:

Chromatographia

Year:

1992

Language:

english

File:

PDF, 502 KB

english, 1992

34

HPLC of individual site glycoforms in serum orosomucoid

M. Treuheit, H. B. Halsall

Journal:

Chromatographia

Year:

1991

Language:

english

File:

PDF, 248 KB

english, 1991

35

Restricted variation in the glycosylation of human α1-acid glycoprotein

M. J. Treuheit, H. B. Halsall

Journal:

Chromatographia

Year:

1993

Language:

english

File:

PDF, 390 KB

english, 1993

36

The glycan patterns at the individual glycosylation sites in orosomucoid from allergic reaction patients

M. J. Treuheit, H. B. Halsall

Journal:

Chromatographia

Year:

1993

Language:

english

File:

PDF, 274 KB

english, 1993

37

The existence of a ligand bound to the serum orosomucoid of cigarette smokers

M. Treuheit, H. B. Halsall

Journal:

Chromatographia

Year:

1991

Language:

english

File:

PDF, 325 KB

english, 1991

38

A method for preparing chelate-cytokine conjugates with retention of protein structure, biological activity, and pharmacokinetic properties

David C Litzinger, Charles M Ransone, Lloyd D Ralph, Wendy Laderach, K Lane Whitcomb, Melissa A Woodward, Ralph W Niven, Michael J Treuheit

Journal:

Journal of Immunological Methods

Year:

1995

Language:

english

File:

PDF, 1.14 MB

english, 1995

39

Sustained in vivo activity of recombinant human granulocyte colony stimulating factor (rHG-CSF) incorporated into hyaluronan

James Meyer, Lane Whitcomb, Michael Treuheit, David Collins

Journal:

Journal of Controlled Release

Year:

1995

Language:

english

File:

PDF, 407 KB

english, 1995

40

Protein nebulization II. Stabilization of G-CSF to air-jet nebulization and the role of protectants

Ralph W. Niven, Steven J. Prestrelski, Michael J. Treuheit, Anna Y. Ip, Tsutomu Arakawa

Journal:

International Journal of Pharmaceutics

Year:

1996

Language:

english

File:

PDF, 821 KB

english, 1996

41

Mono-N-terminal poly(ethylene glycol)–protein conjugates

Olaf Kinstler, Graham Molineux, Michael Treuheit, David Ladd, Colin Gegg

Journal:

Advanced Drug Delivery Reviews

Year:

2002

Language:

english

File:

PDF, 163 KB

english, 2002

42

Disease-coupled specificity in the glycan structures of orosomucoid

Michael J. Treuheit, H.Brian Halsall

Journal:

Clinica Chimica Acta

Year:

1992

Language:

english

File:

PDF, 174 KB

english, 1992

43

Inactivation of the Na,K-ATPase by modification of Lys-501 with 4-acetamido-4′-isothiocyanatostilbene-2,2′-disulfonic acid (SITS)

Carlos H. Pedemonte, Torence L. Kirley, Michael J. Treuheit, Jack H. Kaplan

Journal:

Year:

1992

Language:

english

File:

PDF, 392 KB

english, 1992

44

Degradation products analysis of an Fc fusion protein using LC/MS methods

Da Ren, Gayathri Ratnaswamy, Jill Beierle, Michael J. Treuheit, David N. Brems, Pavel V. Bondarenko

Journal:

International Journal of Biological Macromolecules

Year:

2009

Language:

english

File:

PDF, 468 KB

english, 2009

45

Misoprostol as a Therapeutic Option for Trigeminal Neuralgia in Patients with Multiple Sclerosis

GISELHER PFAU, MICHAEL BRINKERS, TIM TREUHEIT, MORITZ KRETZSCHMAR, MERT SENTüRK, THOMAS HACHENBERG

Journal:

Year:

2012

Language:

english

File:

PDF, 129 KB

english, 2012

46

Probing the Pro- and Anti-Coagulant Interactions of Thrombin

Treuheit, Nicholas A., Komives, Elizabeth A.

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 39 KB

english, 2012

47

The effects of alpha-helix on the stability of Asn residues: Deamidation rates in peptides of varying helicity

Andrew A. Kosky, Ursula O. Razzaq, Michael J. Treuheit, David N. Brems

Journal:

Protein Science

Year:

1999

Language:

english

File:

PDF, 191 KB

english, 1999

48

Screening and Sequencing of Glycated Proteins by Neutral Loss Scan LC/MS/MS Method

Gadgil, Himanshu S., Bondarenko, Pavel V., Treuheit, Michael J., Ren, Da

Journal:

Analytical Chemistry

Year:

2007

Language:

english

File:

PDF, 232 KB

english, 2007

49

Site-Specific Conjugation of Diethylenetriaminepentaacetic Acid to Recombinant Human Granulocyte-Colony-Stimulating Factor: Preservation of Protein Structure and Function

Ralph, Lloyd D., Ransone, Charles M., Treuheit, Michael, Lauren, Scott, Katta, Viswanatham, Litzinger, David C.

Journal:

Year:

1995

Language:

english

File:

PDF, 2.00 MB

english, 1995

50

Small-Angle Neutron Scattering Study of a Monoclonal Antibody Using Free-Energy Constraints

Clark, Nicholas J., Zhang, Hailiang, Krueger, Susan, Lee, Hyo Jin, Ketchem, Randal R., Kerwin, Bruce, Kanapuram, Sekhar R., Treuheit, Michael J., McAuley, Arnold, Curtis, Joseph E.

Journal:

Journal of Physical Chemistry B

Year:

2013

Language:

english

File:

PDF, 1.65 MB

english, 2013